PTEN

PTEN is a gene found in humans which encodes for the protein PTEN, also known as phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. PTEN acts as a tumor suppressor gene through the action of its phosphatase protein product. Mutations of this gene are linked to many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.